Differences in Cell Death and BMP-2 Expression in Core Biopsy Specimens of Malignant Bone Tumors Given Hydrogen Peroxide Compared to Liquid Nitrogen

Introduction: Malignant bone tumors have a global prevalence of 1% the overall malignancy case, with very low 5-year survival rate and high local recurrence. The limb-salvage surgery recycling is widely developed in management malignant tumors. Hydrogen peroxide liquid nitrogen are mediator agents destroying tumor cells while preserving healthy bones as much possible. purpose this study was to compare effectiveness hydrogen number cell deaths using Huvos score BMP-2 expression Materials Method: In vitro experimental research performed on 30 core needle biopsy samples divided into 2 groups nitrogen. parameters measured level. Results: Based study, characteristics were dominated by primary (83.9%), female patients (53.3%) an average age years. Liquid gave better results than peroxide, marked lower (average 12.13 vs. 18.87, p=0.033) higher 39.53 ± 26.59 63.87 27.61, p=0.020). Conclusion: effective agent for